Publications Archives

By ef

Posted September 27, 2022

GRAd-COV2 vaccine provides potent and durable humoral and cellular immunity to SARS-CoV-2 in randomised placebo-controlled phase 2 trial (COVITAR)

· GRAd-COV2 vaccine based on a recently developed group C gorilla adenoviral vector · Phase 2 trial confirms favorable safety profile for single and double dose regimens · [...]

By ef

In News, Publications

Posted July 15, 2022

Engineered Sleeping Beauty Transposon as Efficient System to Optimize Chimp Adenoviral Production

Sleeping Beauty (SB) is the first DNA transposon employed for efficient transposition in vertebrate cells, opening new applications for genetic engineering and gene therapies. A transposonbased [...]

By ef

In News, Publications

Posted January 25, 2022

Strong immunogenicity of heterologous prime-boost immunizations with the experimental vaccine GRAd-COV2 and BNT162b2 or ChAdOx1-nCOV19

Originally published on npj Vaccines volume 6, Article number: 131 (2021). Chiara Agrati, Stefania Capone, Concetta Castilletti, Eleonora Cimini, Giulia Matusali, Silvia Meschi, Eleonora [...]

By ef

In News, Publications

Posted January 24, 2022

GRAd-COV2, a gorilla adenovirus-based candidate vaccine against COVID-19, is safe and immunogenic in younger and older adults

Originally published on Sci Transl Med. 2021 Oct 26. doi: 10.1126/scitranslmed. abj1996.

By ef

In News, Publications

Posted January 23, 2022

Immunogenicity of a new gorilla adenovirus vaccine candidate for COVID-19

Originally published on Molecular Therapy Volume 29, Issue 8, 4 August 2021, Pages 2412-2423 Stefania Capone, Angelo Raggioli, Michela Gentile, Simone Battella, Armin Lahm, Andrea Sommella, [...]

By ef

In News, Publications

Posted January 22, 2022

MAIT cell activation augments adenovirus vector vaccine immunogenicity

Originally published on Science. 2021 Jan 29;371(6528):521-526. doi:10.1126/science.aax8819.PMID: 33510029. Capone S, Brown A, Hartnell F, Sorbo MD, Traboni C, Vassilev V, Colloca S, Nicosia A, [...]

By ef

In News, Publications

Posted January 21, 2022

A next generation vaccine against human rabies based on a single dose of a chimpanzee adenovirus vector serotype C

Originally published on PLoS neglected tropical diseases. 2020 Jul 15. 14(7): e0008459. doi: 10.1371/ journal. pntd.0008459.

By ef

In News, Publications

Posted June 23, 2020

MHC class II invariant chain–adjuvanted viral vectored vaccines enhances T cell responses in humans

Originally published on SCIENCE TRANSLATIONAL MEDICINE • 17 Jun 2020 • Vol 12, Issue 548. Ilaria Esposito, Paola Cicconi, Anna Morena D’Alise, Anthony Brown, Marialuisa Esposito, Leo [...]

By fabiocrognale

In News, Publications

Posted April 4, 2019

Novel genetically-modified chimpanzee adenovirus and MVA-vectored respiratory syncytial virus vaccine safely boosts humoral and cellular immunity in healthy older adults

Originally published on Journal of Infection 2019 Feb 8. pii: S0163-4453(19)30038-6. doi: 10.1016/j.jinf.2019.02.003. Green CA, Sande CJ, Scarselli E, Capone S, Vitelli A, Nicosia A, Silva-Reyes [...]